NFL Week 6 brings another important group of injuries to monitor across the league, with several key players dealing with injuries that could impact their availability this week.
Here are the latest NFL Week 6 injury updates, practice participation reports, player statuses and return timelines from around the league.
This article will be updated through Saturday as teams release their final injury reports and game-day designations.
Ashton Jeanty, Raiders - Foot/Ankle
Jeanty is beginning to feel significantly better as he continues dealing with foot and ankle injuries, according to head coach Klint Kubiak. Kubiak also dismissed reports that the Raiders were considering resting Jeanty for a week to allow him additional recovery time.
Caleb Williams, Bears - Hamstring
Williams was listed as an estimated full participant Wednesday as he continues recovering from a hamstring injury that has sidelined him for the past three games. Thursday's practice participation will provide further clarity on his potential return in Week 6 against the Falcons.
Michael Penix Jr., Falcons - Ribs
Penix is expected to start in Week 6 against the Bears as long as he does not experience any setbacks with his rib injury, according to head coach Kevin Stefanski. He suffered the injury during Sunday night's Week 5 game against the Ravens.
Baker Mayfield, Buccaneers - Thumb
Mayfield has not resumed throwing and did not practice Wednesday as he continues recovering from a dislocated thumb suffered in Week 3. Head coach Todd Bowles confirmed Mayfield has yet to begin throwing, putting his availability beyond Week 6 in question. Jalon Daniels will start Sunday against the Steelers.
Lamar Jackson, Ravens - Ankle
Jackson did not practice Wednesday as he continues recovering from an ankle injury that sidelined him in Week 5. He remains day-to-day ahead of Week 6 against the Browns.
Rashee Rice, Chiefs - Hamstring
Rice did not practice Wednesday due to a hamstring injury suffered in Week 4 against the Raiders. Head coach Andy Reid previously described the injury as a minor tweak, but Rice remains sidelined despite having a bye week to recover. His availability for Week 6 is now in question.
A.J. Brown, Patriots - Ankle
Brown has been designated to return from injured reserve and is expected to resume practicing Wednesday; he was a limited participant. The Patriots now have a 21-day window to activate him, with a potential return as early as Week 6 against the Jets.
Jeremiyah Love, Cardinals - Ankle
Love will did practice Wednesday as he continues dealing with ankle issues, according to head coach Mike LaFleur. He is still managing a high ankle sprain suffered during the preseason and may have injured his other ankle in Week 4. LaFleur said the team plans to give Love additional rest and evaluate his progress throughout the week, leaving his availability for Week 6 uncertain.
TreVeyon Henderson, Patriots - High Ankle Sprain
Henderson was limited in Wednesday's practice despite reports that he is expected to miss multiple weeks with a high ankle sprain suffered in Week 5 against the Raiders. He was not spotted during the portion of practice open to the media but reportedly participated later in the session. His availability for Week 6 against the Jets remains uncertain, although his limited participation is an encouraging development.
Quinshon Judkins, Browns - Ankle
Judkins did not practice Wednesday due to an ankle injury suffered during Sunday's Week 5 game against the Jets. He was seen wearing a walking boot after the game, leaving his availability for Week 6 against the Ravens uncertain.
Breece Hall, Jets - Quad
Hall could miss his third consecutive game in Week 6 against the Patriots as he continues to deal with a quad injury, according to The Athletic's Zack Rosenblatt. He did not practice on Wednesday. He has missed the past two games, and head coach Aaron Glenn continues to consider him week-to-week.
Kyle Monangai, Bears - Thumb/Toe
Monangai was listed as an estimated non-participant for Wednesday's walkthrough as he continues dealing with thumb and toe injuries. He missed all three practices last week before being ruled out for Week 5. His continued absence raises concerns about his availability for Week 6 against the Falcons. Starting running back D'Andre Swift (hip) was not listed on the injury report.
Saquon Barkley, Eagles - Hamstring
Barkley did not practice Wednesday as he continues recovering from a hamstring injury that sidelined him in Week 5. His availability for Week 6 remains uncertain.
DeVonta Smith, Eagles - Hamstring/Toe
Smith did not practice Wednesday due to hamstring and toe injuries. He missed Week 5 with a hamstring injury and has yet to return to practice, leaving his availability for Week 6 uncertain.
Ladd McConkey, Chargers - Foot
McConkey returned to practice Wednesday as a limited participant after missing all three practices last week due to a foot injury. He was active for Week 5 against the Broncos but did not play a snap. His return to practice is an encouraging sign for his availability in Week 6 against the Chiefs.
Alvin Kamara, Saints - Back
Kamara was limited in Wednesday's practice as he continues dealing with a back injury. He played through the issue in Week 5 but recorded just five touches, while Kendre Miller had 10 carries and CJ Donaldson led the backfield in snaps. The Saints appear to be managing Kamara's workload as he works through the injury.
Tank Dell, Texans - Knee
Dell is practicing in full ahead of Week 6 against the Jaguars in London as he continues recovering from a multi-ligament knee tear suffered in 2024. If he travels with the team, it could signal a potential return to game action for the first time since the injury.
Kenyon Sadiq, Jets - Concussion
Sadiq remains in the NFL's concussion protocol after suffering a head injury during Week 5 against the Browns that forced him out of the game. His availability for Week 6 remains uncertain. Mason Taylor led the Jets' tight ends with a 59% route participation rate against Cleveland, catching all three targets for 23 yards.
David Montgomery, Texans - Groin
Montgomery did not practice Wednesday due to a groin injury suffered during Week 5 against the Titans. Head coach DeMeco Ryans previously described him as week-to-week, leaving his availability for Week 6 against the Jaguars uncertain.
Tre' Harris, Chargers - Hamstring
Harris did not practice Wednesday after suffering a hamstring injury during Week 5 against the Broncos. His availability for Week 6 against the Chiefs remains uncertain.
Chris Olave, Saints - Illness
Olave did not practice Wednesday due to an illness. His absence does not currently appear related to an injury setback.
Rico Dowdle, Steelers - Toe
Dowdle was limited in Wednesday's practice as he continues dealing with a toe injury.
