NFL Week 6 brings another important group of injuries to monitor across the league, with several key players dealing with injuries that could impact their availability this week.
Here are the latest NFL Week 6 injury updates, practice participation reports, player statuses and return timelines from around the league.
This article will be updated through Saturday as teams release their final injury reports and game-day designations.
Friday, October 16th
OUT
Lamar Jackson, Ravens - Ankle
Jackson has been ruled out for Week 6 against the Browns, head coach Jesse Minter confirmed Friday. He will miss his second consecutive game due to an ankle injury despite earlier reports suggesting he had a realistic chance to return this week. Jackson did not practice Wednesday or Thursday, and his recovery remains ongoing.
Baker Mayfield, Buccaneers - Thumb
Mayfield has been ruled out for Week 6 against the Steelers as he continues recovering from a thumb injury suffered in Week 3. He did not practice at any point this week and has yet to resume throwing. Jalon Daniels will start in his absence, while Mayfield's availability for Week 7 against the Panthers remains uncertain.
Jalen Hurts, Eagles - Calf (Blood Clot)
Hurts has been ruled out for Week 6 against the Panthers after a follow-up ultrasound revealed movement in a superficial blood clot in his calf. Tanner McKee will start in his absence.
Jeremiyah Love, Cardinals - Ankle
Love has been ruled out for Week 6 against the Rams after missing all three practices this week due to an ankle injury. Head coach Mike LaFleur said Love is not currently a candidate for injured reserve, although his continued absence raises concerns about a potential multi-week recovery.
Rashee Rice, Chiefs - Hamstring
Rice has been ruled out for Week 6 against the Chargers as he continues recovering from a hamstring strain suffered in Week 4. He did not practice Wednesday or Thursday despite the Chiefs' Week 5 bye.
Saquon Barkley, Eagles - Hamstring
Barkley has been ruled out for Week 6 against the Panthers as he continues recovering from a hamstring injury. He missed Week 5 against the Jaguars and did not practice Wednesday or Thursday, marking his second consecutive missed game.
Breece Hall, Jets - Quad
Hall has been ruled out for Week 6 against the Patriots due to a quad injury, head coach Aaron Glenn confirmed Friday. He did not practice Wednesday or Thursday and will miss his third game of the season.
Adonai Mitchell, Jets - Finger
Mitchell has been ruled out for Week 6 against the Patriots as he continues recovering from a finger injury. He did not practice Wednesday or Thursday and will miss his fourth consecutive game.
Kyle Monangai, Bears - Thumb/Toe
Monangai has been ruled out for Week 6 against the Falcons due to thumb and toe injuries, marking his second consecutive missed game. Head coach Ben Johnson said Monangai is trending in the right direction but remains week-to-week. D'Andre Swift is expected to handle an increased workload in his absence.
David Montgomery, Texans - Groin
Montgomery has been ruled out for Week 6 against the Jaguars in London and will not travel with the team. He suffered a groin injury in Week 5 against the Titans and did not practice Wednesday. Head coach DeMeco Ryans previously described him as week-to-week.
Tank Dell, Texans - Knee
Dell has been ruled out for Week 6 against the Jaguars in London and will not travel with the team. He continues recovering from a multi-ligament knee tear suffered in 2024 despite practicing in full earlier this week.
IN
Michael Penix Jr., Falcons - Ribs
Penix has been removed from the injury report and is cleared to play in Week 6 against the Bears. He suffered a rib injury in Week 5 against the Ravens but returned to full practice Thursday. His removal from the injury report confirms he is ready to start Sunday.
Zay Flowers, Ravens - Toe
Flowers has been removed from the final injury report and is cleared to play in Week 6 against the Browns. He was added to the injury report Thursday with a toe injury and was limited in practice Thursday and Friday. Despite the limited participation, Flowers carries no injury designation heading into Sunday's game.
DeVonta Smith, Eagles - Hamstring/Toe
Smith has been removed from the final injury report and is cleared to play in Week 6 against the Panthers. He missed Wednesday's practice before returning as a limited participant Thursday and upgrading to full participation Friday. Smith told reporters he is "good" and said the toe injury is no longer an issue. He missed Week 5 against the Jaguars due to a hamstring injury.
Ladd McConkey, Chargers - Foot
McConkey has been removed from the injury report and is cleared to play in Week 6 against the Chiefs. He was active in Week 5 against the Broncos but did not play a snap due to a foot injury. Head coach Jim Harbaugh said he was unsure whether McConkey would face a snap count in his return.
KC Concepcion, Browns - Concussion
Concepcion has cleared the NFL's concussion protocol and will play in Week 6 against the Ravens, head coach Todd Monken confirmed Friday. He suffered the injury in Week 5 against the Jets and was limited in Thursday's practice before receiving clearance to return.
QUESTIONABLE
Caleb Williams, Bears - Hamstring
Williams is questionable for Week 6 against the Falcons as he continues recovering from a hamstring tear that has sidelined him for three games. He was limited in practice last week before participating fully this week. Head coach Ben Johnson said the team expects more clarity on his availability after Williams completes the final stress tests in his return-to-play plan.
A.J. Brown, Patriots - Ankle
Brown is questionable for Week 6 against the Jets as he continues recovering from an ankle injury. He was limited in practice Wednesday and Thursday after being designated to return from injured reserve earlier this week. Head coach Mike Vrabel said the team will decide Saturday whether to activate Brown, providing clarity on his availability before Sunday's game.
TreVeyon Henderson, Patriots - Ankle
Henderson is questionable for Week 6 against the Jets after being limited in practice throughout the week. He suffered a high ankle sprain in Week 5 against the Raiders, with initial reports suggesting he could miss multiple weeks. Henderson told reporters Friday that he was surprised to be practicing so soon and said he is feeling "pretty good," an encouraging sign for his availability Sunday.
Quinshon Judkins, Browns - Ankle
Judkins is questionable for Week 6 against the Ravens after returning to practice Friday as a limited participant. He did not practice Wednesday or Thursday due to an ankle injury suffered in Week 5 against the Jets. His availability remains uncertain, and he could face a limited workload if cleared to play.
Tyler Warren, Colts - Groin
Warren is questionable for Week 6 against the Titans after suffering a groin injury during Friday's practice. He was added to the injury report following the setback, leaving his availability for Sunday's game uncertain.
Alvin Kamara, Saints - Back
Kamara is questionable for Week 6 against the Giants as he continues dealing with a back injury. He participated in practice throughout the week despite being limited Wednesday. His consistent participation is an encouraging sign for his availability Sunday, although his status remains uncertain.
DJ Moore, Bills - Shoulder
Moore is questionable for Week 6 against the Raiders as he continues recovering from a shoulder injury. He did not practice Wednesday or Thursday before returning Friday, following the same pattern as last week when he was ultimately ruled out on game day. His availability remains uncertain and could come down to a game-time decision.
DK Metcalf, Steelers - Illness
Metcalf is questionable for Week 6 against the Buccaneers due to an illness. His availability remains uncertain as the Steelers deal with multiple absences at wide receiver. Michael Pittman is on injured reserve, while Roman Wilson and Ben Skowronek have been ruled out. Metcalf's status will be important to monitor ahead of Sunday's game.
Rico Dowdle, Steelers - Toe
Dowdle is questionable for Week 6 against the Buccaneers as he continues recovering from a toe injury. He was limited in practice Wednesday before participating fully Thursday and Friday, an encouraging sign for his availability. However, head coach Mike McCarthy has indicated that Jaylen Warren will continue handling a significant workload even if Dowdle returns.
Ja'Kobi Lane, Ravens - Wrist
Lane is questionable for Week 6 against the Browns despite practicing fully throughout the week. Head coach Jesse Minter praised Lane's performance in practice but stopped short of confirming whether he would play Sunday, saying the team would make that determination. His full participation is an encouraging sign for a potential return.
Thursday, October 15th
Jalen Hurts, Eagles - Calf (Blood Clot)
Hurts has been ruled out for Week 6 against the Panthers after the Eagles announced Thursday that a superficial blood clot was discovered in his calf. He was listed as a full participant in Friday's practice ahead of Week 5 against the Jaguars despite a calf injury and entered Sunday's game in London without an injury designation. The team released a statement detailing the evaluation process that led to the discovery.
Caleb Williams, Bears - Hamstring
Williams was a full participant in practice Wednesday and Thursday as he continues recovering from a hamstring injury that has sidelined him for three games. Williams confirmed Thursday that he suffered a hamstring tear but declined to disclose the grade. Despite his full practice participation, he said he still needs to pass additional tests before being cleared to play in Week 6.
Lamar Jackson, Ravens - Ankle
Jackson did not practice Thursday, marking his second consecutive absence as he continues recovering from an ankle injury that sidelined him in Week 5. His availability for Week 6 against the Browns remains uncertain, with Tyler Huntley likely to start if Jackson cannot play. Head coach Jesse Minter previously said Jackson would not need much practice time to be cleared for a return.
Michael Penix Jr., Falcons - Ribs
Penix was a full participant in Thursday's practice as he continues recovering from a rib injury suffered in Week 5 against the Ravens. Head coach Kevin Stefanski previously indicated that Penix was expected to start in Week 6 against the Bears barring any setbacks. His full participation is an encouraging sign for his availability.
Rashee Rice, Chiefs - Hamstring
Rice did not practice Thursday, marking his second consecutive absence as he continues recovering from a hamstring strain suffered in Week 4. Head coach Andy Reid initially described the injury as a minor tweak, but The Athletic's Mike Silver reported that Rice could miss several weeks. Despite the Chiefs' Week 5 bye, Rice has yet to return to practice, raising concerns about his availability for Week 6.
Zay Flowers, Ravens - Toe
Flowers was added to the injury report Thursday due to a toe injury after playing through a foot issue in Week 5. It remains unclear whether the toe injury is related to his previous foot issue. His production was limited with Tyler Huntley running the offense.
A.J. Brown, Patriots - Ankle
Brown was limited in practice Thursday for the second consecutive day as he continues recovering from an ankle injury. He was designated to return from injured reserve earlier this week, opening a 21-day window for the Patriots to activate him. His availability for Week 6 against the Jets remains uncertain.
TreVeyon Henderson, Patriots - Ankle
Henderson was limited in practice Thursday for the second consecutive day despite reports that he could miss multiple weeks with a high ankle sprain suffered in Week 5 against the Raiders. His continued participation is an encouraging sign, although his availability for Week 6 against the Jets remains uncertain.
DeVonta Smith, Eagles - Hamstring/Toe
Smith was limited in Thursday's practice after sitting out Wednesday due to hamstring and toe injuries. He missed Week 5 against the Jaguars with a hamstring injury, making his return to practice an encouraging sign ahead of Week 6.
Saquon Barkley, Eagles - Hamstring
Barkley did not practice Thursday, marking his second consecutive absence as he continues recovering from a hamstring injury. He missed Week 5 against the Jaguars and has been considered week-to-week, leaving his availability for Week 6 uncertain.
Mike Evans, 49ers - Achilles/Ribs
Evans will not practice Thursday due to Achilles soreness and a rib injury. He was cleared to play in Week 5, but his latest injury concerns leave his availability for Week 6 uncertain.
Jalen Coker, Panthers - Quad
Coker was a full participant in Thursday's practice for the second consecutive day despite a quad injury. His continued full participation is an encouraging sign for his availability in Week 6.
Quinshon Judkins, Browns - Ankle
Judkins did not practice Thursday, marking his second consecutive absence as he continues recovering from an ankle injury suffered in Week 5 against the Jets. He was seen wearing a walking boot after Sunday's game, and his availability for Week 6 against the Ravens is increasingly in doubt.
KC Concepcion, Browns - Concussion
Concepcion was limited in Thursday's practice as he continues working through the NFL's concussion protocol. He suffered the injury during Week 5 against the Jets and was ruled out for the remainder of the game. His limited participation gives him a chance to clear protocol ahead of Week 6 against the Ravens, although his availability remains uncertain.
Denzel Boston, Browns - Foot
Boston was limited in practice Wednesday and Thursday due to a foot injury. He has participated in both sessions this week, but his status for Week 6 against the Ravens remains uncertain ahead of Friday's final injury report.
Breece Hall, Jets - Quad
Hall did not practice Thursday, marking his second consecutive absence as he continues recovering from a quad injury. He has missed the past two games, and head coach Aaron Glenn previously described him as week-to-week. His availability for Week 6 against the Patriots remains in doubt.
Adonai Mitchell, Jets - Finger
Mitchell did not practice Thursday for the second consecutive day due to a finger injury. He has been sidelined since Week 2 and missed Week 5 against the Browns, leaving his availability for Week 6 against the Patriots uncertain.
David Montgomery, Texans - Groin
Montgomery has been ruled out for Week 6 against the Jaguars in London and will not travel with the team. He suffered a groin injury in Week 5 against the Titans and did not practice Wednesday. Head coach DeMeco Ryans previously described him as week-to-week.
Tank Dell, Texans - Knee
Dell has been ruled out for Week 6 against the Jaguars in London and will not travel with the team. He continues recovering from a multi-ligament knee tear suffered in 2024 despite practicing in full earlier this week.
Wednesday, October 14th
Ashton Jeanty, Raiders - Foot/Ankle
Jeanty is beginning to feel significantly better as he continues dealing with foot and ankle injuries, according to head coach Klint Kubiak. Kubiak also dismissed reports that the Raiders were considering resting Jeanty for a week to allow him additional recovery time.
Caleb Williams, Bears - Hamstring
Williams was listed as an estimated full participant Wednesday as he continues recovering from a hamstring injury that has sidelined him for the past three games. Thursday's practice participation will provide further clarity on his potential return in Week 6 against the Falcons.
Michael Penix Jr., Falcons - Ribs
Penix is expected to start in Week 6 against the Bears as long as he does not experience any setbacks with his rib injury, according to head coach Kevin Stefanski. He suffered the injury during Sunday night's Week 5 game against the Ravens.
Baker Mayfield, Buccaneers - Thumb
Mayfield has not resumed throwing and did not practice Wednesday as he continues recovering from a dislocated thumb suffered in Week 3. Head coach Todd Bowles confirmed Mayfield has yet to begin throwing, putting his availability beyond Week 6 in question. Jalon Daniels will start Sunday against the Steelers.
Lamar Jackson, Ravens - Ankle
Jackson did not practice Wednesday as he continues recovering from an ankle injury that sidelined him in Week 5. He remains day-to-day ahead of Week 6 against the Browns.
Rashee Rice, Chiefs - Hamstring
Rice did not practice Wednesday due to a hamstring injury suffered in Week 4 against the Raiders. Head coach Andy Reid previously described the injury as a minor tweak, but Rice remains sidelined despite having a bye week to recover. His availability for Week 6 is now in question.
A.J. Brown, Patriots - Ankle
Brown has been designated to return from injured reserve and is expected to resume practicing Wednesday; he was a limited participant. The Patriots now have a 21-day window to activate him, with a potential return as early as Week 6 against the Jets.
Jeremiyah Love, Cardinals - Ankle
Love will did practice Wednesday as he continues dealing with ankle issues, according to head coach Mike LaFleur. He is still managing a high ankle sprain suffered during the preseason and may have injured his other ankle in Week 4. LaFleur said the team plans to give Love additional rest and evaluate his progress throughout the week, leaving his availability for Week 6 uncertain.
TreVeyon Henderson, Patriots - High Ankle Sprain
Henderson was limited in Wednesday's practice despite reports that he is expected to miss multiple weeks with a high ankle sprain suffered in Week 5 against the Raiders. He was not spotted during the portion of practice open to the media but reportedly participated later in the session. His availability for Week 6 against the Jets remains uncertain, although his limited participation is an encouraging development.
Quinshon Judkins, Browns - Ankle
Judkins did not practice Wednesday due to an ankle injury suffered during Sunday's Week 5 game against the Jets. He was seen wearing a walking boot after the game, leaving his availability for Week 6 against the Ravens uncertain.
Breece Hall, Jets - Quad
Hall could miss his third consecutive game in Week 6 against the Patriots as he continues to deal with a quad injury, according to The Athletic's Zack Rosenblatt. He did not practice on Wednesday. He has missed the past two games, and head coach Aaron Glenn continues to consider him week-to-week.
Kyle Monangai, Bears - Thumb/Toe
Monangai was listed as an estimated non-participant for Wednesday's walkthrough as he continues dealing with thumb and toe injuries. He missed all three practices last week before being ruled out for Week 5. His continued absence raises concerns about his availability for Week 6 against the Falcons. Starting running back D'Andre Swift (hip) was not listed on the injury report.
Saquon Barkley, Eagles - Hamstring
Barkley did not practice Wednesday as he continues recovering from a hamstring injury that sidelined him in Week 5. His availability for Week 6 remains uncertain.
DeVonta Smith, Eagles - Hamstring/Toe
Smith did not practice Wednesday due to hamstring and toe injuries. He missed Week 5 with a hamstring injury and has yet to return to practice, leaving his availability for Week 6 uncertain.
Ladd McConkey, Chargers - Foot
McConkey returned to practice Wednesday as a limited participant after missing all three practices last week due to a foot injury. He was active for Week 5 against the Broncos but did not play a snap. His return to practice is an encouraging sign for his availability in Week 6 against the Chiefs.
Alvin Kamara, Saints - Back
Kamara was limited in Wednesday's practice as he continues dealing with a back injury. He played through the issue in Week 5 but recorded just five touches, while Kendre Miller had 10 carries and CJ Donaldson led the backfield in snaps. The Saints appear to be managing Kamara's workload as he works through the injury.
Tank Dell, Texans - Knee
Dell is practicing in full ahead of Week 6 against the Jaguars in London as he continues recovering from a multi-ligament knee tear suffered in 2024. If he travels with the team, it could signal a potential return to game action for the first time since the injury.
Kenyon Sadiq, Jets - Concussion
Sadiq remains in the NFL's concussion protocol after suffering a head injury during Week 5 against the Browns that forced him out of the game. His availability for Week 6 remains uncertain. Mason Taylor led the Jets' tight ends with a 59% route participation rate against Cleveland, catching all three targets for 23 yards.
David Montgomery, Texans - Groin
Montgomery did not practice Wednesday due to a groin injury suffered during Week 5 against the Titans. Head coach DeMeco Ryans previously described him as week-to-week, leaving his availability for Week 6 against the Jaguars uncertain.
Tre' Harris, Chargers - Hamstring
Harris did not practice Wednesday after suffering a hamstring injury during Week 5 against the Broncos. His availability for Week 6 against the Chiefs remains uncertain.
Chris Olave, Saints - Illness
Olave did not practice Wednesday due to an illness. His absence does not currently appear related to an injury setback.
Rico Dowdle, Steelers - Toe
Dowdle was limited in Wednesday's practice as he continues dealing with a toe injury.
