Most Injured NFL Teams in the 2025 NFL Season

As the 2025 NFL season unfolded, injuries became a defining storyline for multiple franchises. From season-ending ligaments to frequent game-to-game absences, certain teams struggled to keep high-impact players on the field.

The SIC Health Score Rating - our proven proprietary player and team health metric highlight which teams were truly beset by injury issues. The Team SIC Score incorporates the health of each player, then position groups and the overall team each week and is updated daily in NFL season.

Below are the top five most injured teams of 2025 including key player injuries that shaped their seasons. For more details create a free account at sicscore.com to access injury ratings, projections, and performance impact analysis for all 32 NFL teams.

1. Arizona Cardinals - 79.5 Average SIC Health Score Rating

Key Cardinals Injuries in 2025

QB Kyler Murray - Out for the season with a foot injury after five games, forcing the Cardinals to pivot to Jacoby Brissett.
RB James Conner - Suffered a season-ending foot injury in Week 3, significantly weakening Arizona’s run game.
RB Trey Benson - Knee injury placed him on injured reserve and ultimately missed nines.
Starlin Thomas V - Season lost to a knee injury before the season began.
WR Marvin Harrison Jr. - Concussion and later appendicitis led to multiple games missed.
Multiple offensive linemen (e.g., G Will Hernandez) and defensive players missed time due to various lower-body injuries.
Overall 13 players missed the majority of the season with IR stints, plus several others missing multiple games.

2. San Francisco 49ers - 81.2 Average SIC Health Score Rating

Key Injuries in 2025

LB Fred Warner - Season-ending fractured and dislocated ankle.
DE Nick Bosa - Torn ACL, out for the season.
DE Mykel Williams - Season-ending torn ACL & meniscus.
QB Brock Purdy - Multiple injuries including shoulder and toe issues that limited availability.
WR Brandon Aiyuk - Knee injury that stopped him from playing in the 2025 campaign.
WR Ricky Pearsall - dealt with a knee injury all season that caused him to miss 7 games.
TE George Kittle & other starters dealt with hamstring and ankle ailments. Kittle's season ended with an Achilles tear in the Wild Card Round.
Overall ten players landed on IR and missed the majority of the season.

Despite returning key veterans at times, the 49ers saw their roster continuity repeatedly disrupted. These injuries collectively weighed on their offensive rhythm and defensive identity throughout the season.

3. Miami Dolphins - 82.9 Average SIC Health Score Rating

Key Injuries in 2025

WR Tyreek Hill - Suffered a season-ending left knee dislocation and torn ACL with additional ligament damage; later released.
Over ten other players landed on IR, missing the majority of the season, and several more missing multiple games.

Miami’s injury story largely revolved around losing its most dynamic offensive weapon early in the year. Hill’s absence substantially affected the Dolphins’ scoring ability and forced personnel adjustments throughout the offense.

4. Washington Commanders - 83.8 Average SIC Health Score Rating

Key Injuries in 2025

QB Jayden Daniels - Missed ten games due to a series of injuries including an elbow dislocation and a hamstring strain.
RB Austin Ekeler - Tore his Achilles in Week 2 and missed the remainder of the season.
DE Deatrich Wise Jr. - Season-ending torn quadriceps.
CB Marshon Lattimore - ACL tear in Week 9 ending his season.
WR Luke McCaffrey - Broken collarbone placed on injured reserve.

This combination of injuries to key offensive and defensive contributors stunted Washington’s development and forced reliance on lesser-experienced roster players.

5. Tampa Bay Buccaneers - 84.1 Average SIC Health Score Rating

Key Buccaneers Injuries in 2025

WR Mike Evans - Suffered hamstring strain and broken collarbone but returned late; missed nine games.
WR Chris Godwin - Missed 8 games with lingering ankle, foot and fibula injuries.
RB Bucky Irving - Missed 7 games with foot and shoulder injuries before returning.
Multiple starters including LT Tristan Wirfs, LB Haason Reddick and CB Jamel Dean missed multiple games throughout the season.

The Buccaneers endured significant offensive absences that impacted depth and scoring output especially in the middle stretch of the 2025 campaign.

Why the SIC Health Score Matters?

The SIC Health Score Rating isn’t merely a count of injuries - it’s a forward-looking rating that can be used to accurately project player and team performance.

A lower score equals worse health, helping analysts, bettors, and fantasy players alike understand how injuries truly affected team performance.

For reference here is our analysis of the 2024 NFL season SIC health ratings.

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