Kyler Murray’s 2025 Injury and Recovery
Updated - November 5 - Kyler Murray was added to the Injured Reserve list meaning he will now miss a minimum of four games.
Kyler Murray is set to miss four straight games due to a mid-foot sprain suffered in Week 5 of the 2025 season. NFL insiders have described the injury as a version of a Lisfranc sprain; while surgery is not needed, the team is prioritizing a full recovery, with an estimated return timeline of 4-8 weeks. Head coach Jonathan Gannon and NFL insiders have emphasized that the decision to keep Murray inactive is entirely based on health concerns, as he has not yet regained his trademark mobility—a key component of his dual-threat skill set.
Murray continues to participate in some practices, logging LP's last week, but has not reached full speed, particularly when running and changing direction. The Cardinals are focused on a cautious rehab process to prevent setbacks and ensure Murray is 100% before returning to game action.
Kyler Murray’s 2025 Season Stats
Before his injury, Murray started five games for the Cardinals in 2025:
Completed 110 of 161 passes (68.3% completion rate)
962 passing yards, 6 touchdowns, 3 interceptions
Averaged 192.4 passing yards per game
Passer rating: 88.6
Added 173 rushing yards and 1 rushing TD
Sacked 16 times for 111 yards lost
His quarterback play displayed solid accuracy, mobility in the pocket, and the ability to extend plays, remaining a stabilizing force for the Cardinals’ offense.
Brissett’s Performance as Backup
With Murray sidelined, Jacoby Brissett has started at quarterback. Data and team analysis suggest that Brissett has played with surprising efficiency, earning one of the highest grades among Cardinals players this season (grade: 75.8, slightly higher than Murray’s 72.1). Under Brissett, the Cardinals’ offense became more balanced and less predictable, with an uptick in efficiency (offensive EPA improved from below average with Murray to a positive rate with Brissett). Third-down efficiency also spiked under Brissett, showing strong game management and decision-making.
Kyler Murray’s Importance to the Cardinals
Despite Brissett’s steadiness, the Cardinals’ identity and future success are closely tied to Murray’s presence:
Murray’s mobility and improvisational ability add a dimension that changes defensive game plans.
The team’s playbook and offensive structure are built around his unique skill set.
When healthy, Murray raises the team’s ceiling and offers a higher upside, especially in must-win situations.
Head coach Jonathan Gannon has made clear that Murray resumes his role as starting quarterback when cleared, underscoring the team’s long-term investment and strategic plans centered around their franchise signal-caller.
Outlook for the Rest of the 2025 Season
Murray’s return will be crucial as the Cardinals are needing to turnaround their season, they are currently sitting on just three wins and bottom of the NFC West. For now, Brissett is ensuring the team remains afloat, but Murray’s progress is the storyline that will define the Cardinals season.
Sign up to our FREE Weekly Newsletter here for all of our best injury-insights, free injury-based picks and special offers!
Want more expert injury insights?
Sign up for a free account and newsletter at Sports Injury Central
👉 Try our proven winning premium tools, projections and picks winning at 62% on spreads this season.
For NFL Week 10 We Guarantee a Winning Week on NFL pregame spreads - sign up, follow our picks and win.
New weekly SIC Picks subscriptions only.
WANT TO KNOW WHO TO BET ON THE NFL? - USE SIC PICKS FOR PROVEN WINNING PICKS CASHING AT 56.5% ON SPREADS OVER SIX YEARS!
SIC PICKS ARE BASED ON INSIDER INJURY KNOWLEDGE FROM FORMER PRO SPORTS TEAM DOCTORS TO GIVE YOU A WINNING EDGE IN SPORTS BETTING!
SIC PICKS are powered by the proven SIC Score algorithms from our exclusive panel of former Pro Sports Team doctors to give you a sports betting edge. Each day our team of doctors analyze the players and teams and share their expert insights to help you make informed bets on the biggest unknown to sportsbooks and sports bettors - player health and injuries!
For our Best Bets including spreads, totals, props and live in game with instant alerts as game day opportunities arise with research notes, sign up to SIC Picks here for less than $2 a day on an annual plan.
Sign up to SIC Picks today to get our picks sent direct to your cell!
