The San Francisco 49ers face the Seattle Seahawks in a pivotal 2025 NFL Week 1 matchup, with both teams aiming for a strong divisional start. The current injury reports and Sports Injury Central insights reveal critical availability questions that will directly impact Sunday’s showdown.

Game Preview: 49ers vs. Seahawks

The season opener at Lumen Field sees the 49ers trying to bounce back from last year's struggles defending the run, while the Seahawks look to capitalize behind new offensive coordinator Klint Kubiak's ground attack. San Francisco's defensive rookies such as CJ West and Alfred Collins will be tested immediately. The 49ers need efficiency from Brock Purdy and likely face an aggressive Seahawks offense led by Sam Darnold. However, both rosters are dealing with notable absences and health concerns, which could swing the outcome.

Here are the players listed on the most recent injury reports for both teams, including their status as of posting Friday afternoon:

49ers Week 1 Injury Report

  • Christian McCaffrey (RB) – Calf, Limited Practice Thursday, Questionable

  • Yetur Gross-Matos (DE) – Knee, Limited Practice, Questionable

  • Jauan Jennings (WR) – Calf, Limited Practice, Questionable

  • Jordan James (RB) – Finger, Limited Practice, Questionable

  • Dominick Puni (OT) – Knee, Limited Practice, Questionable

  • Jordan Watkins (WR) – Ankle, Limited Practice, Questionable

Seahawks Week 1 Injury Report

  • Uchenna Nwosu (LB) – Knee, Questionable

  • Cody White (WR) – Shoulder, Questionable

  • Dareke Young (WR) – Hamstring, Questionable

  • Jake Bobo (WR) – Concussion, Questionable

  • Anthony Bradford (G) - Back, Questionable

  • Riq Woolen (CB) - Illness, Questionable

Injury Impact and Key Takeaways

  • 49ers: If McCaffrey is limited, expect a heavier load for backups like Isaac Guerendo, putting pressure on Purdy to produce with a shorthanded offense. Defensive health among rookie linemen is also pivotal.

  • Seahawks: The loss of several starters on the line weakens both pass protection and the run game. Questionable statuses across multiple positions could limit Seattle’s ability to take full advantage of the 49ers.

Injury news and projected availability at kickoff should be watched right up to 90 minutes prior to game time for any last-minute shifts, as both teams’ health situations could tip the scales in this divisional clash. Let us do the hard work, follow SIC PIcks and SIC Data for all the latest projections and analysis.

Matchup Breakdown: Position Groups Impacted by Injuries

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