Game Preview: 49ers and Buccaneers Clash in Crucial NFC Matchup
The 2025 NFL Week 6 Sunday showdown features the San Francisco 49ers traveling to face the Tampa Bay Buccaneers, with both teams seeking to solidify their place in the NFC playoff race. Both clubs enter the game at 4-1, coming off close wins—San Francisco edged out the Rams last Thursday, while Tampa Bay survived a shootout against Seattle with a last-second field goal. This contest not only showcases dynamic offenses but is marked by significant injury concerns for both rosters, making it one of the most unpredictable matchups this week.
Latest Injury and Practice Reports
Stay up to date with the most current, major injury news as both teams finalize their Week 6 preparation:
San Francisco 49ers Injury Report:
Brock Purdy (QB): Did Not Participate (Toe)—OUT, but trending toward missing Sunday's game
Mac Jones (QB): Limited Participant (Knee/Oblique)—Questionable - butexpected in the lineup if Purdy sits
Ricky Pearsall (WR): DNP (Knee)—OUT
Jauan Jennings (WR): Limited Participant (Ankle/Rib)—made it back to practice this week, possible boost if cleared
Defensive Line: Robert Beal (DL, ankle) DNP, Yetur Gross-Matos DNP OUT (DL, knee), Alfred Collins (DT, knee) LP Questionable, Kalia Davis (DL, hand) LP Questionable, Kevin Givens (DL, pectoral) LP OUT
Upton Stout (CB, ankle) Questionable
Jordan Watkins (WR, Calf) DNP OUT
Christian McCaffrey (RB): Full Participant (rest)—ready to start
Tampa Bay Buccaneers Injury Report:
Mike Evans (WR): DNP (Hamstring) - OUT
Chris Godwin (WR): DNP (Shin) - yet to fully recover, OUT
Bucky Irving (RB): DNP (Foot/Shoulder) - OUT
Zyon McCollum (CB): DNP (Thumb) OUT, Benjamin Morrison (CB): DNP - OUTsecondary will be depleted
Christian Izien (S): LP (Quad), Jamel Dean (CB): FP (Hip) - some defensive backs returning, but not at full strength
Lavonte David (LB): LP (Knee) - veteran leader banged up but often plays through pain
Josh Williams (RB, concussion) OUT
Impact of Key Injuries
Both teams are limping into this NFC clash, which could tip the balance based on who is able to return by Sunday:
49ers: The quarterback situation is the week’s top storyline, with Brock Purdy’s toe injury keeping his availability in doubt. If Purdy cannot go, the offense will turn to Mac Jones, who is also dealing with his own knee issue. San Francisco’s receiving corps continues to battle injuries - if Jauan Jennings returns, he’ll be vital to supporting whichever quarterback starts. Several defensive linemen are banged up but hope to suit up, giving a boost if available.
Buccaneers: The loss of Mike Evans and Chris Godwin dramatically limits Tampa Bay’s passing attack. Baker Mayfield may need to lean heavily on the run game and rookie Emeka Egbuka. The secondary is also thin, although Jamel Dean's full return to practice offers some hope.
Want more expert injury insights?
Sign up for a free account and newsletter at Sports Injury Central
👉 Try our proven winning premium tools, projections and picks. For NFL Week 6 get a Guaranteed Pick! New weekly SIC Picks subscribers get a refund if the guaranteed pick loses! Our guaranteed picks went 10-4 on Spreads last season!
Sports Injury Central (SIC) is raising the bar for NFL betting confidence in 2025.
For the first time ever, SIC is offering a guaranteed winning record on NFL regular-season pregame spread picks from SIC Picks — or subscribers will receive a refund of their annual SIC Picks subscription.
This bold offer is available exclusively to the first 100 new annual SIC Picks subscribers and is powered by the same data-driven algorithms that have made SIC the go-to source for injury analysis, performance projections and predictive betting insights.
👉 Secure Your Guaranteed Season - SIGN UP NOW HERE
WANT TO KNOW WHO TO BET ON THE NFL? - USE SIC PICKS FOR PROVEN WINNING PICKS CASHING AT 56.5% ON SPREADS OVER SIX YEARS!
SIC PICKS ARE BASED ON INSIDER INJURY KNOWLEDGE FROM FORMER PRO SPORTS TEAM DOCTORS TO GIVE YOU A WINNING EDGE IN SPORTS BETTING!
SIC PICKS are powered by the proven SIC Score algorithms from our exclusive panel of former Pro Sports Team doctors to give you a sports betting edge. Each day our team of doctors analyze the players and teams and share their expert insights to help you make informed bets on the biggest unknown to sportsbooks and sports bettors - player health and injuries!
For our Best Bets including spreads, totals, props and live in game with instant alerts as game day opportunities arise with research notes, sign up to SIC Picks here for less than $2 a day on an annual plan.
Sign up to SIC Picks today to get our picks sent direct to your cell!
