Buffalo Bills star edge rusher Von Miller suffered a right knee injury in the Thanksgiving game against the Lions and has been ruled out.By video, Miller's right foot appeared to stick in the turf and his knee appeared to shift when his right foot was stepped on by Lions center Frank Ragnow.Based on one angle, the Pro Football Docs have significant worry for a right knee ACL tear.Full analysis: https://t.co/HaGH8SJQK1By video, our panel of doctors have significant worry Von Miller suffered a season-ending knee injury on this play#NFL #BillsMafia pic.twitter.com/YzExWDtqcy— Sports Injury Central (@SICscore) November 24, 2022 Bills Mafia can hope Miller was able to escape serious injury, but the video does not look great for the two-time Super Bowl champion. Miller will have to get a positive result on MRI to avoid missing the rest of the season.The best case scenario would be an MCL sprain or a high ankle sprain from when he was landed on by the lineman.Miller was able to walk off the field, but was carted to the locker room after being checked out in the injury tent.Miller suffered a torn ACL in his right knee in Week 16, 2013, when he was with the Broncos. He returned for the start of the 2014 season and finished with 14 sacks that year, good enough for Pro Bowl and All-Pro second team honors.An ACL can re-tear even after reconstructive surgery, as was the case with Odell Beckham Jr. in last year’s Super Bowl.Shortly after Miller exited, Beckham tweeted this:GET RID OF TURF.— Odell Beckham Jr (@obj) November 24, 2022 The eight-time All Pro's exit before halftime leaves the Bills thin at the pass rushing spot.Greg Rousseau and A.J. Epenesa are both inactive for the game with ankle injuries.The 33-year-old linebacker had 8 sacks entering the game, which was tied for 10th most in the league.