NFL Week 6 Biggest Injury Headlines 

  1. Chargers: Major OL injuries, plus WR and secondary clusters against Kansas City.

  2. Ravens: Lamar Jackson uncertain and extensive OL injuries.

  3. Browns: Multiple defensive linemen DNP, along with RB and OL concerns.

  4. Eagles: Barkley and Smith DNP, with additional WR/OL injuries.

  5. Broncos: Surtain and Hufanga OUT, Moss questionable against Seattle.

  6. Patriots: Five CBs on the injury report.

  7. Cardinals: Severe secondary injuries and Paris Johnson OFS.

  8. 49ers: Extensive existing DL and WR injuries.

  9. Packers: Defensive-line and secondary injuries, Parsons unavailable.

  10. Giants: Both offensive tackles DNP.

  11. Jaguars: Four CBs on the report.

  12. Colts: Three receivers injured, including two DNPs.

Our Week 6 NFL injury report breaks down the biggest injuries for every matchup, including key starters, players on injured reserve (IR), practice participation, potential absences and injury clusters that could create advantages on the field. We highlight the most important injury news, how each team's overall health could affect performance and which matchups present the biggest injury-related betting angles heading into Week 6.

1. Chargers vs. Chiefs — Chargers Offensive Line Crisis, Multiple WR/Secondary Injuries

Chargers

  • OL: LT Rashawn Slater (high ankle, ongoing absence); RT Joe Alt (neck, DNP); G Kayode Awosika (fibula, DNP); C Tyler Biadasz (ACL, IR); OL Trey Pipkins (knee, IR).

  • WR: Tre Harris (DNP); Quentin Johnston (chest, LP); Ladd McConkey (foot, LP); Brenen Thompson (LP); KeAndre Lambert-Smith (LP, IR return window).

  • Secondary: S Derwin James (hamstring, DNP); CB Donte Jackson (hamstring, DNP); S Elijah Molden (LP).

  • Front seven: EDGE Khalil Mack (DNP); EDGE Bud Dupree (LP); LB Daiyan Henley (LP).

Chiefs

  • WR: Rashee Rice (hamstring, DNP).

  • OL: OT Josh Simmons (LP).

  • CB: L'Jarius Sneed (LP).

  • QB: Patrick Mahomes (FP).

Injury clusters: Chargers OL (five), WR (five), secondary (three), plus pass-rush concerns.

Betting and Fantasy Football angle: Herbert's protection is the biggest concern against Kansas City's pass rush. The Chargers are also missing key defensive personnel, while Rice's hamstring could reduce Mahomes' receiving options.

2. Ravens vs. Browns — Lamar Jackson Uncertain, Ravens Center Crisis, Browns DL Decimated

Ravens

  • QB: Lamar Jackson (ankle, DNP).

  • OL: C Cam Jurgens (concussion, LP); LT Ronnie Stanley (LP); RT Roger Rosengarten (LP); G Andrew Vorhees (foot, LP); G John Simpson (LP); C Danny Pinter (knee, IR); C Ethan Pocic (knee, IR); C Jovaughn Gwyn (fibula/ankle, IR).

  • DL/EDGE: Calais Campbell (DNP); Trey Hendrickson (finger, FP).

  • WR: Rashod Bateman (LP).

  • CB: Marlon Humphrey (calf, LP).

Browns

  • DL: Maliek Collins (DNP); Mason Graham (knee/ankle, DNP); Mike Hall Jr. (ankle, DNP); Kalia Davis (quad, DNP); Derek Barnett (DNP); Alex Wright (Achilles, OFS).

  • OL: Tytus Howard (DNP); Teven Jenkins (back, DNP); Elgton Jenkins (LP).

  • RB: Quinshon Judkins (DNP); Dylan Sampson (DNP).

  • LB: Carson Schwesinger (DNP).

  • WR: Denzel Boston (LP); KC Concepcion (LP).

Injury clusters: Ravens OL/center (eight), Browns DL (six), OL (three), RB (two).

Betting and Fantasy Football angle: Jackson's availability is the largest individual variable. Baltimore's offensive line is compromised, but Cleveland's depleted defensive front could offset that disadvantage. Both Browns running backs also missed practice.

3. Panthers vs. Eagles — Philadelphia QB/RB/WR Injuries, Hurts Out, Barkley and Smith DNP

Eagles

  • Jalen Hurts - (blood clot, OUT)

  • RB: Saquon Barkley (hamstring, DNP); Will Shipley (DNP).

  • WR: DeVonta Smith (hamstring/toe, DNP); Marquise Brown (ankle, LP); Dontayvion Wicks (hamstring, LP).

  • OL: C Drew Kendall (knee, DNP); G Landon Dickerson (knee, IR return window, LP); G Tyler Steen (LP).

  • EDGE: Jalyx Hunt (DNP); Jonathan Greenard (ankle, LP).

  • Secondary: Michael Carter II (DNP); Marcus Epps (LP).

Panthers

  • OL: Monroe Freeling (DNP); Damien Lewis (LP).

  • RB: AJ Dillon (DNP).

  • EDGE: Jaelan Phillips (LP).

  • TE: Darren Waller (LP); Tommy Tremble (LP).

Injury clusters: Eagles RB (two), WR (three), OL (three); Panthers OL (two), TE (two).

Betting and Fantasy Football angle: Barkley and Smith headline Philadelphia's injury concerns, with additional offensive-line issues. Carolina has its own protection and tight-end injuries, but the Eagles have the more significant offensive personnel questions.

4. Jets vs. Patriots — New England Cornerback Crisis

Patriots

  • CB: Carlton Davis III (neck, DNP); Karon Prunty (hamstring, DNP); Christian Gonzalez (shoulder, LP); Marcus Jones (LP); Channing Canada (hamstring, LP).

  • WR: A.J. Brown (ankle, IR return window, LP).

  • OL: LT Will Campbell (LP); OT Morgan Moses (foot, LP).

  • RB: TreVeyon Henderson (LP).

Jets

  • RB: Breece Hall (quad, DNP).

  • WR: Adonai Mitchell (finger, DNP).

  • OL: Dylan Parham (DNP).

  • EDGE: Joseph Ossai (DNP).

Injury clusters: Patriots CB (five), Jets RB/WR/OL.

Betting and Fantasy Football angle: New England's secondary is one of the week's most compromised units, although Gonzalez is back practicing. The Jets may struggle to exploit it if Hall and Mitchell cannot play. A.J. Brown's potential return is a significant offensive development.

5. Steelers vs. Buccaneers — Baker Mayfield Thumb Injury, Pittsburgh Secondary/DL

Steelers

  • Secondary: CB Jalen Ramsey (wrist, DNP); CB Jamel Dean (ankle, LP); S DeShon Elliott (knee, LP).

  • DL/EDGE: Cameron Heyward (DNP); Keeanu Benton (DNP); T.J. Watt (LP).

  • WR: Roman Wilson (DNP).

  • RB: Rico Dowdle (LP).

Buccaneers

  • QB: Baker Mayfield (thumb, DNP).

  • WR: Chris Godwin Jr. (DNP).

  • Secondary: S Antoine Winfield Jr. (DNP); CB Benjamin Morrison (LP).

  • RB: Sean Tucker (DNP).

  • OL: LT Tristan Wirfs (FP).

Injury clusters: Steelers secondary (three), defensive front (three); Buccaneers QB/WR and secondary (two).

Betting and Fantasy Football angle: Mayfield's injury is the biggest individual concern. Pittsburgh has multiple defensive starters on the report, potentially weakening the unit facing Tampa Bay's replacement quarterback.

6. Saints vs. Giants — Giants OT Crisis, Saints Front Seven and OL

Saints

  • Front seven: LB Kaden Elliss (calf, DNP); EDGE Anfernee Jennings (knee, DNP); DT Nathan Shepherd (DNP); EDGE Tyree Wilson (LP).

  • RB: Alvin Kamara (back, LP); Travis Etienne Jr. (hamstring, IR).

  • WR: Chris Olave (hamstring, DNP).

  • OL: LT Kelvin Banks Jr. (IR); LG Dillon Radunz (IR).

Giants

  • OL: LT Andrew Thomas (groin, DNP); OT Jermaine Eluemunor (DNP).

  • Secondary: S Tyler Nubin (DNP); CB Colton Hood (DNP); CB Greg Newsome II (LP); S Jason Pinnock (concussion, LP).

  • EDGE: Abdul Carter (DNP).

  • TE: Theo Johnson (LP).

Injury clusters: Saints front seven (four), OL (two), RB (two); Giants OT (two), secondary (four).

Betting and Fantasy Football angle: Both Giants tackles missed practice, creating protection concerns, although the Saints' front seven is also weakened. New Orleans has additional losses on the left side of its offensive line and at running back.

7. Seahawks vs. Broncos — Denver Secondary Decimated

Seahawks

  • RB: Zach Charbonnet (knee, LP, OUT).

  • LB: Drake Thomas (ankle, DNP, OUT); Chazz Surratt (calf, DNP, OUT).

  • DL: Leonard Williams (LP).

Broncos

  • CB: Patrick Surtain II (ankle, DNP, OUT); Riley Moss (ribs, LP, QUESTIONABLE).

  • S: Talanoa Hufanga (ankle, DNP, OUT).

Injury clusters: Broncos secondary (three); Seahawks LB (two), RB (one).

Betting and Fantasy Football angle: Denver is missing Surtain and Hufanga, with Moss questionable, creating an important advantage for Seattle's passing game. The Seahawks are missing two linebackers and Charbonnet.

8. Texans vs. Jaguars — Jacksonville CB Cluster, Houston Front Seven

Texans

  • Front seven: EDGE Will Anderson Jr. (ankle, LP); EDGE Jadeveon Clowney (LP); LB Azeez Al-Shaair (groin, DNP); LB Henry To'oTo'o (LP).

  • OL: OT Trent Brown (DNP).

  • WR: Nico Collins (LP); Tank Dell (knee, FP).

  • RB: David Montgomery (DNP).

  • S: Jalen Pitre (DNP).

Jaguars

  • CB: Montaric Brown (DNP); Jarrian Jones (LP); Jaylon Jones (hamstring, LP); Jourdan Lewis (LP).

  • S: Eric Murray (concussion, LP).

  • OL: Emmanuel Pregnon (LP); Cole Van Lanen (LP).

Injury clusters: Texans front seven (four); Jaguars CB (four), secondary (five).

Betting and Fantasy Football angle: Jacksonville's entire CB rotation is on the report, potentially benefiting Houston's passing game. The Texans' defensive-front injuries could also affect their ability to pressure Jacksonville.

9. Bears vs. Falcons — Chicago LB Injuries, Both Starting QBs FP

Bears

  • LB: T.J. Edwards (DNP); Keyshaun Elliott (DNP).

  • EDGE: Dayo Odeyingbo (DNP).

  • RB: Kyle Monangai (thumb/toe, DNP).

  • QB: Caleb Williams (hamstring, FP).

Falcons

  • QB: Michael Penix Jr. (ribs, FP).

  • EDGE: Za'Darius Smith (concussion/neck, LP).

  • LB: Divine Deablo (hamstring, LP).

  • CB: C.J. Henderson (groin, DNP).

  • OL: Jake Matthews (groin, FP).

Injury clusters: Bears LB (two), front seven (three); Falcons EDGE/LB (two).

Betting and Fantasy Football angle: Both quarterbacks practiced fully after recent injuries. Chicago's linebacker absences could hurt run defense and intermediate coverage, while Atlanta's front-seven injuries could affect its pass rush.

10. Titans vs. Colts — Indianapolis WR Cluster, Tennessee RB Injuries

Titans

  • RB: Tony Pollard (foot, DNP); Tyjae Spears (LP).

  • EDGE: John Franklin-Myers (back, DNP).

  • Secondary: S Kevin Winston Jr. (DNP); S Amani Hooker (concussion, LP); CB Marcus Harris (LP).

Colts

  • WR: Keenan Allen (groin, DNP); Ashton Dulin (hamstring, DNP); Josh Downs (LP); Darius Slayton (FP).

  • OL: Jalen Travis (DNP); Matt Goncalves (LP).

  • CB: Charvarius Ward (groin, DNP).

  • LB: Jaylon Carlies (ribs, DNP).

  • RB: Jonathan Taylor (LP).

Injury clusters: Colts WR (three), OL (two); Titans RB (two), secondary (three).

Betting and Fantasy Football angle: Indianapolis has multiple receivers dealing with injuries, including two DNPs. Tennessee's RB injuries could limit offensive balance, while its secondary remains compromised.

11. Cardinals vs. Rams — Arizona Secondary and Offensive Line Crisis

Cardinals

  • Secondary: S Budda Baker (DNP); S Wydett Williams Jr. (DNP); S Andrew Wingard (DNP); S Kitan Crawford (LP); CB Will Johnson (neck, IR).

  • OL: G Isaac Seumalo (DNP); LT Paris Johnson Jr. (torn biceps, OFS).

  • EDGE: Josh Sweat (DNP).

  • RB: Jeremiyah Love (ankle, DNP).

Rams

  • TE: Davis Allen (DNP); Colby Parkinson (LP).

  • LB: Nate Landman (LP).

  • CB: Josh Wallace (LP).

  • Suspension: LT Alaric Jackson (reported one-game suspension; Week 6 out

Injury clusters: Cardinals secondary (five), OL (two); Rams TE (two).

Betting and Fantasy Football angle: Arizona has major injuries at safety and cornerback, potentially creating passing opportunities for the Rams. Paris Johnson's season-ending injury also leaves the Cardinals weakened at left tackle.

12. Cowboys vs. Packers — Green Bay DL/Secondary Injuries, Parsons Unavailable

Cowboys

  • CB: Cobie Durant (DNP); Ameer Speed (DNP); Joey Porter Jr. (LP).

  • Front seven: Von Miller (DNP); DeMarvion Overshown (DNP).

  • OL: Drew Shelton (DNP); Tyler Guyton (FP); Tyler Smith (FP).

  • WR: CeeDee Lamb (FP).

Packers

  • DL: Javon Hargrave (toe, DNP); Jonathan Ford (DNP); Devonte Wyatt (LP); Jordon Riley (LP).

  • Secondary: Keisean Nixon (DNP); Benjamin St-Juste (DNP); Evan Williams (LP).

  • OL: Aaron Banks (knee/toe, LP); Jacob Monk (quad, LP).

  • EDGE: Micah Parsons (ACL rehabilitation, expected unavailable).

Injury clusters: Packers DL/EDGE (five), secondary (three), OL (two); Cowboys CB (three), front seven (two).

Betting and Fantasy Football angle: Green Bay is compromised along its defensive line and in the secondary, which could benefit Dallas' offense. The Cowboys also have defensive-back injuries, but Lamb and two important offensive linemen practiced fully.

13. Bills vs. Raiders — Buffalo DL/WR Injuries, Raiders DT Cluster

Bills

  • DL: Ed Oliver (knee, DNP); T.J. Sanders (knee, LP).

  • WR: DJ Moore (DNP); Joshua Palmer (LP).

  • OL: Spencer Brown (back, LP).

  • CB: Dee Alford (LP).

Raiders

  • RB: Ashton Jeanty (ankle/foot, FP).

  • TE: Brock Bowers (knee, LP).

  • WR: Jalen Nailor (DNP).

  • DL: Tonka Hemingway (DNP); Foley Fatukasi (LP).

  • OL: Trey Zuhn III (LP).

Injury clusters: Bills DL (two), WR (two); Raiders DL (two).

Betting and Fantasy Football angle: Buffalo's defensive interior could be vulnerable if Oliver is unavailable. Jeanty's full practice is encouraging for Las Vegas, although Bowers remains limited and Nailor missed practice.

14. Commanders vs. 49ers — San Francisco DL/WR Crisis, Washington WR Injuries

Monday Night Football — practice reports pending

Commanders

  • WR: Stefon Diggs (hamstring, missed Week 5); Terry McLaurin (hamstring, recent injury).

  • OL: LT Laremy Tunsil (triceps, OFS).

  • QB: Jayden Daniels (elbow, returned Week 5).

49ers

  • DL/EDGE: Nick Bosa (knee/calf, missed Week 5); Alfred Collins (knee, previously IR); CJ West (knee, previously IR); Mikail Kamara (previously IR); Sam Okuayinonu (previously IR).

  • WR: Ricky Pearsall (PCL, previously IR); Christian Kirk (calf, previously IR); Demarcus Robinson (ankle, previously IR); De'Zhaun Stribling (previously IR); Mike Evans (ribs, played Week 5).

Injury clusters: 49ers DL/EDGE (five), WR (five); Commanders WR (two), OL (one).

Betting and Fantasy Football angle: San Francisco's defensive line and receiving corps remain significantly compromised. Washington's receiver injuries and Tunsil's absence could limit its offense, although Daniels has returned.