NFL Week 6 Biggest Injury Headlines
Eagles QB/RB: Jalen Hurts, Saquon Barkley and Will Shipley OUT.
Chargers OL/secondary: Alt, Awosika, James and Donte Jackson OUT, along with Tre Harris.
Ravens QB/center: Lamar Jackson and Cam Jurgens OUT.
Browns DL: Hall and Davis OUT, with Graham and Barnett questionable.
Cardinals secondary: Two safeties OUT, two more questionable.
Packers defensive front: Hargrave and Ford OUT, Riley doubtful, Parsons an existing absence.
Buccaneers QB: Baker Mayfield OUT, with multiple secondary injuries.
Bears front seven: Edwards, Elliott and Odeyingbo OUT.
Jets offense: Breece Hall, Adonai Mitchell and Dylan Parham OUT.
Texans offense: David Montgomery and Tank Dell OUT.
Giants secondary/OL: Hood and Nubin OUT, both tackles questionable.
Commanders secondary: Four defensive backs questionable for Monday.
Our Week 6 NFL injury report breaks down the biggest injuries for every matchup, including key starters, players on injured reserve (IR), practice participation, potential absences and injury clusters that could create advantages on the field. We highlight the most important injury news, how each team's overall health could affect performance and which matchups present the biggest injury-related betting angles heading into Week 6.
1. Chargers vs. Chiefs — Chargers OL and Secondary Crisis
Chargers
OL: Joe Alt (neck, OUT); Kayode Awosika (fibula, OUT); Rashawn Slater (high ankle, existing absence); Tyler Biadasz (ACL, previously listed IR); Trey Pipkins (knee, previously listed IR).
WR: Tre Harris (hamstring, OUT); KeAndre Lambert-Smith (hamstring, Q); Brenen Thompson (quad, Q).
Secondary: Derwin James (hamstring, OUT); Donte Jackson (hamstring, OUT); Rodney Shelley (hamstring, DOUBTFUL).
Front seven: Bud Dupree (neck, Q); Daiyan Henley (knee, Q); Dalvin Tomlinson (hamstring, Q); Jamaree Caldwell (knee, Q).
Chiefs
WR: Rashee Rice (hamstring/knee, OUT).
OL: Josh Simmons (back, OUT).
CB: L'Jarius Sneed (knee, Q).
Injury clusters: Chargers OL, secondary, WR and defensive front.
Injury angle: Los Angeles has significant losses at both tackle/guard and in its defensive backfield. Kansas City should have opportunities to generate pressure and exploit the secondary, although Rice's absence and Simmons' injury also weaken the Chiefs. This remains one of the week's clearest health mismatches.
2. Ravens vs. Browns — Lamar Jackson OUT, Baltimore Center and Cleveland DL Injuries
Ravens
QB: Lamar Jackson (ankle, OUT); Tyler Huntley expected to start.
OL: Cam Jurgens (concussion, OUT); Andrew Vorhees (foot, Q); Emery Jones Jr. (ankle, Q). Existing center-depth concerns remain relevant.
DL: Broderick Washington (ankle, OUT).
WR: Ja'Kobi Lane (wrist, Q).
Browns
QB: Dillon Gabriel (back, OUT).
RB: Dylan Sampson (knee, OUT); Quinshon Judkins (ankle, Q).
OL: Teven Jenkins (back, OUT).
DL: Kalia Davis (quad, OUT); Mike Hall Jr. (ankle, OUT); Mason Graham (knee/ankle, Q); Derek Barnett (ankle, Q); Alex Wright (Achilles, existing OFS).
LB: Carson Schwesinger (ankle, Q).
Injury clusters: Ravens QB/center; Browns defensive line, RB and OL.
Injury angle: Baltimore is missing its starting quarterback and center, while Cleveland has major defensive-line injuries and could be without both key running backs. The Browns' depleted interior defense may partially offset Baltimore's protection issues.
3. Panthers vs. Eagles — Jalen Hurts, Saquon Barkley and Will Shipley OUT
Eagles
QB: Jalen Hurts (calf blood clot, OUT; IR placement reported); Tanner McKee expected to start.
RB: Saquon Barkley (hamstring, OUT); Will Shipley (foot, OUT).
OL: Landon Dickerson (knee, Q); Drew Kendall (knee, Q).
EDGE: Jalyx Hunt (knee/ankle, OUT); A.J. Epenesa (back, DOUBTFUL).
Secondary: Michael Carter II (abdomen, OUT); Jakorian Bennett (knee, Q).
TE: Grant Calcaterra (back, Q); Eli Stowers (quad, Q).
WR: DeVonta Smith and Dontayvion Wicks have no final injury designation and are expected to be available.
Panthers
RB: AJ Dillon (ankle, OUT); Trevor Etienne (ankle, Q).
OL: Monroe Freeling (knee, DOUBTFUL); Taylor Moton (lung, Q); Damien Lewis (elbow, Q).
Defensive front: Tershawn Wharton (neck, Q); Jaelan Phillips (hamstring, Q).
Injury clusters: Eagles QB/RB/OL, EDGE; Panthers OL/RB.
Injury angle: This is a substantial change from Wednesday. Philadelphia is without Hurts and its top two running backs, forcing a major offensive adjustment with McKee. The Eagles also have protection concerns and multiple defensive injuries. Carolina's offensive-line health remains important, but Philadelphia has the more significant quarterback and backfield losses.
4. Jets vs. Patriots — Jets Offensive Injuries, Patriots CB Cluster
Jets
RB: Breece Hall (quad, OUT).
WR: Adonai Mitchell (finger, OUT); Omar Cooper Jr. (ankle, Q).
OL: Dylan Parham (knee, OUT).
EDGE: Joseph Ossai (ankle, OUT).
TE: Kenyon Sadiq (concussion, Q).
Defense: Francisco Mauigoa (quad, Q); Dane Belton (knee, Q).
Patriots
CB: Carlton Davis III (neck, OUT); Karon Prunty (hamstring, OUT); Channing Canada (hamstring, Q).
WR: A.J. Brown (ankle, Q on Friday; activated from IR Saturday).
RB: TreVeyon Henderson (ankle, Q).
OL: Will Campbell (knee, Q); Marcus Bryant (ankle, Q).
LB/S: Christian Elliss (chest, Q); Craig Woodson (shoulder, Q).
Injury clusters: Patriots CB (three), Jets RB/WR/OL.
Injury angle: New England is missing two cornerbacks, but the Jets have lost Hall, Mitchell and Parham, reducing their ability to exploit that weakness. Brown's activation is an important positive development for the Patriots' offense.
5. Steelers vs. Buccaneers — Baker Mayfield OUT, Both Secondaries Compromised
Steelers
WR: Roman Wilson (finger, OUT); Ben Skowronek (calf, OUT); DK Metcalf (illness, Q).
Secondary: DeShon Elliott (knee, OUT); Jalen Ramsey (wrist, Q); Jamel Dean (ankle, Q).
DL: Keeanu Benton (ankle, Q).
RB: Rico Dowdle (toe, Q).
TE: Pat Freiermuth (calf, Q, added to report Saturday).
Buccaneers
QB: Baker Mayfield (right thumb, OUT); Jalon Daniels expected to start.
WR: David Sills V (hamstring, OUT).
Secondary: Antoine Winfield Jr. (rib, OUT); Benjamin Morrison (quad, DOUBTFUL); Ayden Garnes (ankle, Q).
LB: SirVocea Dennis (ankle/foot, Q); Josiah Trotter (knee, Q).
RB: Sean Tucker (quad, Q).
Injury clusters: Steelers WR/secondary; Buccaneers QB/secondary/LB.
Injury angle: Mayfield's absence is the headline, but Pittsburgh is also dealing with significant defensive-back and receiver injuries. Tampa Bay's secondary is missing Winfield and likely Morrison, potentially giving Pittsburgh an advantage through the air despite its own receiver concerns.
6. Saints vs. Giants — New Orleans Front Seven, Giants Secondary and OT
Saints
LB/EDGE: Kaden Elliss (calf, OUT); Anfernee Jennings (knee, OUT).
DL: Nathan Shepherd (illness, Q).
RB: Alvin Kamara (back, Q); Travis Etienne Jr. (hamstring, previously listed IR).
WR: Chris Olave (illness, Q).
CB: Lorenzo Styles Jr. (knee, Q).
OL: Kelvin Banks Jr. and Dillon Radunz (previously listed IR; current roster status requires confirmation).
Giants
OL: Andrew Thomas (groin, Q); Jermaine Eluemunor (calf, Q).
Secondary: Colton Hood (concussion, OUT); Tyler Nubin (neck, OUT).
EDGE: Abdul Carter (calf, Q).
TE: Theo Johnson (neck, OUT).
Injury clusters: Saints front seven and existing OL absences; Giants secondary, offensive tackles and TE.
Injury angle: The Giants have lost two defensive backs and their starting tight end, with both offensive tackles questionable. New Orleans is missing two important linebackers, which could help the Giants' running game, but New York's protection issues remain a major concern.
7. Texans vs. Jaguars — Houston Offensive Skill Injuries, Jacksonville CB Cluster
Texans
RB: David Montgomery (groin, OUT).
WR: Tank Dell (knee, OUT); Nico Collins (limited during the week, no final designation).
S: Jalen Pitre (shoulder, OUT).
LB: Henry To'oTo'o (shoulder, Q).
CB: Ja'Marcus Ingram (elbow, Q).
EDGE: Will Anderson Jr. and Jadeveon Clowney appeared on the practice report but have no final injury designation.
Jaguars
CB: Montaric Brown (hamstring, OUT); Jaylon Jones (hamstring, Q).
Special teams: Ross Matiscik (shoulder, OUT).
Injury clusters: Texans RB/WR and secondary; Jaguars CB.
Injury angle: Houston is without Montgomery and Dell, reducing its offensive versatility. Pitre's absence is also significant defensively. Jacksonville's cornerback injuries could create opportunities for Nico Collins and Marvin Harrison Jr., making the passing matchup particularly important.
8. Bears vs. Falcons — Chicago LB Cluster, Caleb Williams Questionable
Bears
QB: Caleb Williams (hamstring, Q; FP Friday).
RB: Kyle Monangai (thumb/toe, OUT).
LB: T.J. Edwards (hamstring, OUT); Keyshaun Elliott (quad, OUT).
EDGE: Dayo Odeyingbo (quad, OUT).
Secondary: Kyler Gordon (calf, Q); Tyrique Stevenson (hip, Q).
Falcons
QB: Michael Penix Jr. (ribs, no designation; expected to start).
CB: C.J. Henderson (groin, OUT).
EDGE: Za'Darius Smith (neck, Q).
Injury clusters: Bears LB/front seven (three OUT), secondary (two Q); Falcons CB/EDGE.
Injury angle: Chicago is missing two linebackers and an edge defender, weakening its front seven against Atlanta's running game. Williams practiced fully but remains questionable, while Penix is cleared to start. The Bears' quarterback decision remains the biggest late variable.
9. Titans vs. Colts — Tennessee Secondary, Indianapolis TE/WR Injuries
Titans
S: Kevin Winston Jr. (quad, OUT).
RB: Tyjae Spears (knee, Q); Tony Pollard (no final designation).
DL: Jordan Elliott (personal, OUT).
Colts
WR: Ashton Dulin (hamstring, OUT).
TE: Tyler Warren (groin, Q); Will Mallory (thumb, IR return consideration).
LB: Jaylon Carlies (ribs, OUT).
WR: Keenan Allen and Josh Downs have no final game designation.
Injury clusters: Titans secondary/RB; Colts TE/WR/LB.
Injury angle: Tennessee's safety depth is weakened, while Indianapolis has an important late injury concern with Warren. Dulin's absence reduces receiver depth, but the Colts' larger offensive concern is whether Warren can play.
10. Cardinals vs. Rams — Arizona Safety Crisis, Jeremiyah Love OUT
Cardinals
RB: Jeremiyah Love (ankle, OUT).
Secondary: Wydett Williams Jr. (concussion, OUT); Andrew Wingard (knee, OUT); Budda Baker (groin, Q); Kitan Crawford (ankle, Q); Will Johnson (neck, previously listed IR).
LB: Zaven Collins (hip, Q).
OL: Paris Johnson Jr. (biceps, existing OFS absence).
Rams
CB: Trent McDuffie (groin, Q).
S: Kamren Curl (ankle, Q).
Injury clusters: Cardinals safety (four), RB and OL; Rams secondary (two).
Injury angle: Arizona's safety group is one of the week's biggest positional injury clusters. Two safeties are ruled out, and two more are questionable. The Rams could exploit the middle of the field, although McDuffie and Curl are important to their own defensive coverage.
11. Cowboys vs. Packers — Green Bay Defensive Line and Secondary Depleted
Cowboys
OL: Drew Shelton (hamstring, OUT).
CB: Cobie Durant (hamstring, OUT); Joey Porter Jr. (ankle, Q); Ameer Speed (knee, Q).
LB: DeMarvion Overshown (hamstring, Q).
DL: LT Overton (foot, Q).
Packers
DL: Jonathan Ford (calf, OUT); Javon Hargrave (Achilles, OUT); Jordan Riley (Achilles, DOUBTFUL); Anthony Campbell (ankle, Q).
CB: Benjamin St-Juste (hamstring, OUT); Brandon Cisse (hip, Q).
OL: Aaron Banks (knee/toe, Q); Jacob Monk (quad, Q).
WR: Skyy Moore (ankle, OUT); Savion Williams (ankle, Q).
EDGE: Micah Parsons (ACL rehabilitation, existing absence).
Injury clusters: Packers DL/EDGE (five), secondary and OL; Cowboys CB (three) and OL.
Injury angle: Green Bay's defensive front is missing Hargrave and Ford, with Riley doubtful and Parsons still unavailable. Dallas should have opportunities to attack the weakened front, although the Cowboys also have significant cornerback injuries. This matchup could favor both passing offenses if the defensive absences hold.
12. Bills vs. Raiders — Buffalo Defensive Interior, Raiders WR/DT
Bills
DL: Ed Oliver (knee, Q); T.J. Sanders (shoulder, Q).
WR: DJ Moore (shoulder, Q); Josh Palmer (shoulder, Q).
CB: Dee Alford (ankle, Q).
Raiders
WR: Dont'e Thornton Jr. (hamstring, OUT).
TE: Carter Runyon (foot, OUT); Brock Bowers (no final designation).
DT: Tonka Hemingway (concussion, OUT).
OL: Trey Zuhn III (knee, Q).
RB: Ashton Jeanty (no final designation).
Injury clusters: Bills defensive line/WR; Raiders WR/DT.
Injury angle: Oliver's knee remains the biggest Buffalo concern, particularly against Jeanty and the Raiders' running game. Las Vegas has lost Thornton and Hemingway, but Jeanty and Bowers have no final injury designation.
13. Commanders vs. 49ers — Washington Backfield and Defensive Injuries
Monday Night Football | Listed designations may be updated before kickoff
Commanders
QB: Marcus Mariota (knee, OUT); Jayden Daniels (no final designation).
RB: Jacory Croskey-Merritt (groin, OUT); Jeremy McNichols (quad, Q).
WR: Stefon Diggs (hamstring, Q).
DL/EDGE: Charles Omenihu (groin/ankle, OUT); Javon Kinlaw (ankle/knee, Q).
LB: Javontae Jean-Baptiste (pectoral, OUT); Jordan Magee (hamstring, Q).
Secondary: Trey Amos (ankle, Q); Percy Butler (hamstring, Q); Nick Cross (illness, Q); Tyler Owens (hamstring, Q).
OL: Lucas Patrick (illness, Q); Laremy Tunsil (triceps, existing OFS absence).
49ers
Defensive front: Nick Bosa (knee/calf, prior absence); Alfred Collins (knee, previously IR); CJ West (knee, previously IR); Mikail Kamara and Sam Okuayinonu (previously listed IR).
WR: Ricky Pearsall (PCL), Christian Kirk (calf), Demarcus Robinson (ankle), De'Zhaun Stribling (previously listed IR); Mike Evans (ribs, played Week 5).
Injury clusters: Commanders RB, secondary (four Q), defensive front; 49ers existing DL/WR injuries.
Injury angle: Washington has multiple defensive backs questionable and significant backfield injuries. San Francisco's previously reported defensive-line and receiver absences remain important, but its current Week 6 statuses require confirmation before being treated as final.
