NFL Week 6 brings four significant quarterback injury situations with major fantasy implications. Caleb Williams and Michael Penix Jr. are trending toward playing, while Jalen Hurts has been ruled out and Lamar Jackson's availability remains uncertain.

Here's how those injuries could impact fantasy football production for key running backs, wide receivers and tight ends across the league.

Caleb Williams, Bears — Hamstring

Williams has missed Chicago's last three games with a hamstring injury, but his return could provide a significant boost to an offense that has struggled in his absence. He was a full participant in practice Wednesday and Thursday ahead of Week 6.

The Bears went 2-1 without Williams, although their offensive production declined over the past two weeks.

Case Keenum started in Week 3 and led Chicago to a win over the Eagles, with the offense generating nearly 400 total yards.

Tyson Bagent returned from a concussion in Week 4 and led the Bears past the Jets, but Chicago relied heavily on its running game, finishing with 232 rushing yards. Bagent completed 25 of 34 passes for 268 yards and one interception, although multiple additional interceptions were overturned by penalties.

The offense struggled considerably in Week 5, with Bagent eventually being replaced by Keenum. The two quarterbacks combined for just 165 passing yards and three interceptions.

Fantasy Impact: Williams' return could provide a much-needed boost to Chicago's passing game and its fantasy-relevant receivers.

In Week 1, the Bears scored 59 points and generated 552 yards of total offense, demonstrating the unit's potential with Williams under center.

Chicago's pass catchers have largely underperformed in fantasy during his absence, including tight end Colston Loveland.

With Williams potentially returning in Week 6, fantasy managers could see increased production throughout the Bears' offense, particularly from receivers and tight ends who have struggled to generate consistent opportunities with Keenum and Bagent.

Jalen Hurts, Eagles — Superficial Blood Clot

Hurts has officially been ruled out for Sunday's Week 6 matchup against the Carolina Panthers after a follow-up ultrasound revealed movement in a superficial blood clot in his calf.

For more information on the injury and his potential return timeline, read Pro Football Doc's analysis.

Philadelphia's offense has been decimated by injuries throughout the season. Saquon Barkley and DeVonta Smith have both missed time with hamstring injuries, while Dallas Goedert previously missed games with a knee injury.

The Eagles' offensive line has also undergone significant changes. All-Pro right tackle Lane Johnson retired, center Cam Jurgens was traded and guard Landon Dickerson has spent time on injured reserve.

The backfield has been further depleted by multi-week injuries to backup running backs Tank Bigsby and Will Shipley.

Tanner McKee will start in Hurts' absence, taking over an offense that has struggled with consistency throughout the season. McKee has made just two career starts, both coming in Week 18 games for Philadelphia.

Fantasy Impact: Hurts' absence creates additional uncertainty for an Eagles offense already dealing with injuries at nearly every position.

McKee's limited starting experience, combined with Philadelphia's offensive line and backfield concerns, could make it difficult for the Eagles to sustain drives and generate consistent scoring opportunities.

If Barkley or Smith returns in Week 6, both remain viable fantasy starters based on their talent and expected roles. However, expectations should be tempered with McKee under center and the offense continuing to deal with significant personnel losses.

3. Lamar Jackson, Ravens — Ankle

Jackson is expected to miss his second consecutive game with an ankle injury after sitting out practice Wednesday and Thursday ahead of Baltimore's Week 6 matchup against the Cleveland Browns.

Tyler Huntley is expected to start again after leading the Ravens to a 30-23 overtime victory over the Atlanta Falcons in Week 5.

Huntley completed 24 of 32 passes for 201 yards and two touchdowns against Atlanta, while Baltimore leaned heavily on its running game, finishing with 208 rushing yards on 35 carries.

Fantasy Impact: Baltimore's Week 5 performance provides a clearer picture of what fantasy managers can expect if Huntley starts again.

Derrick Henry carried the ball 24 times for 102 yards, while Justice Hill added 73 yards on just four carries. With Jackson sidelined, Baltimore could continue relying heavily on its backfield to generate offense.

Zay Flowers remained heavily involved in the passing game, catching eight passes for 53 yards. His 6.6 yards per reception reflected the shorter passing approach with Huntley under center.

Flowers remains a strong PPR option because of his reception volume, although his big-play potential may be limited. Henry should continue to see a significant workload as Baltimore relies on its running game to support Huntley.

4. Michael Penix Jr., Falcons — Ribs

Penix was a full participant in practice Wednesday and Thursday after suffering a rib injury during Atlanta's Week 5 overtime loss to the Baltimore Ravens.

Penix took a hard hit late in regulation and was unable to return for overtime. Tua Tagovailoa replaced him but threw a game-ending interception.

Despite the injury, Penix appears on track to start against the Chicago Bears in Week 6.

Fantasy Impact: Penix's availability is particularly important for Drake London, whose production has improved dramatically since Penix returned to the lineup in Week 3.

London caught just six passes for 80 yards across Atlanta's first two games with Cooper Rush at quarterback.

Over the past three games with Penix, London has recorded 21 receptions for 408 yards, including a nine-catch, 194-yard performance against Green Bay and seven receptions for 118 yards against Baltimore.

That represents an increase from 40 receiving yards per game with Rush to 136 yards per game with Penix.

London should remain a strong fantasy starter if Penix plays, with the quarterback change having a significant impact on his receiving production.

Bijan Robinson's fantasy outlook is less dependent on who starts at quarterback. Robinson remains a must-start running back regardless of whether Penix or Tagovailoa is under center.