Our Week 10 NFL injury report breaks down the biggest injuries for every matchup, including key starters, players on injured reserve (IR), practice participation, potential absences and injury clusters that could create advantages on the field. We highlight the most important injury news, how each team's overall health could affect performance and which matchups present the biggest injury-related betting angles heading into Week 10.

1. Patriots vs. Lions — New England Backfield Crisis

New England Patriots

  • RB: Rhamondre Stevenson (knee/plantaris, DNP), TreVeyon Henderson (illness, DNP, OUT)

  • WR: A.J. Brown (knee/ankle, LP), Romeo Doubs (shoulder, IR)

  • TE: Hunter Henry (foot, LP), Cameron Latu (back, DNP)

  • OL: Ben Brown (knee, DNP), Walter Rouse (concussion, DNP), Morgan Moses (foot, LP), Greg Van Roten (hamstring, LP)

  • CB: Carlton Davis III (knee, DNP), Charles Woods (hamstring, LP)

  • S: Brenden Schooler (hamstring, DNP), Kevin Byard (chest, LP)

Detroit Lions

  • QB: Jared Goff (chest, LP)

  • RB: Sione Vaki (ankle, DNP), Isiah Pacheco (back, IR)

  • WR: Amon-Ra St. Brown (ribs, LP)

  • C: Cade Mays (ankle, DNP)

  • CB: D.J. Reed (hip, DNP)

  • S: Kerby Joseph (knee, LP), Brian Branch (hip, LP)

Injury clusters: Patriots RB, OL and secondary; Lions secondary.

Impact: New England could be without both Stevenson and Henderson, leaving Corey Kiner as the primary backfield option. Detroit has concerns in its secondary, but Brown's possible return could improve New England's passing game.

2. Rams vs. Cardinals — Both Passing Games Depleted

Los Angeles Rams

  • WR: Puka Nacua (knee/toe, DNP), Davante Adams (IR), Jordan Whittington (IR)

  • TE: Terrance Ferguson (ankle/hamstring, DNP), Davis Allen (oblique, LP), Colby Parkinson (ribs, LP)

  • OL: Steve Avila (hamstring, DNP)

  • EDGE: Myles Garrett (knee, LP, activated from IR)

  • CB: Trent McDuffie (back, DNP)

  • S: Kamren Curl (toe, DNP)

Arizona Cardinals

  • QB: Gardner Minshew (elbow, IR), Carson Beck expected starter

  • RB: Bam Knight (concussion, LP), James Conner (IR), Trey Benson (IR)

  • WR: Michael Wilson (neck, IR/OFS)

  • TE: Hunter Long (knee, IR — designated to return)

  • OL: Hjalte Froholdt (concussion, DNP), Jon Gaines II (ankle, DNP), Jayden Williams (knee, LP)

  • DL: Roy Lopez (toe/ankle, DNP), Zach Carter (IR — designated to return), Dante Stills (shoulder, LP)

  • LB: Mack Wilson Sr. (knee/ankle, DNP)

  • CB: Max Melton (knee/hand, LP)

Injury clusters: Rams WR, TE and secondary; Arizona QB, WR and OL.

Impact: The Rams are missing multiple important receiving options, while Arizona is preparing to start Beck without Wilson. Garrett's return creates a potentially significant pass-rush advantage against an injured Cardinals offensive line.

3. Seahawks vs. Raiders — Seattle Quarterback and Offensive Line

Seattle Seahawks

  • QB: Sam Darnold (quadriceps/ribs, DNP), Drew Lock (elbow/oblique, LP)

  • OL: Charles Cross (ankle, DNP), Quenton Nelson (knee, DNP), Anthony Bradford (knee, LP)

  • DL: Brandon Pili (back, DNP), Leonard Williams (stinger, DNP), Jarran Reed (personal, DNP)

  • EDGE: Derick Hall (back, LP), Uchenna Nwosu (ankle, LP), Connor O'Toole (foot, LP)

  • LB: Patrick O'Connell (toe, LP)

  • WR: Jake Bobo (IR)

  • TE: Elijah Arroyo (IR)

Las Vegas Raiders

  • DT: Thomas Booker (ankle, LP), Folorunso Fatukasi (shoulder/back, LP)

  • OL: Trey Zuhn III (concussion, LP)

  • RB: Chris Collier (IR)

  • EDGE: Brennan Jackson (IR)

  • CB: Chigozie Anusiem (IR)

Injury clusters: Seattle QB, OL and defensive front; Las Vegas defensive interior.

Impact: Seattle has major offensive concerns with Darnold unavailable and Lock managing two injuries. Cross and Nelson also missed practice, creating significant protection concerns. Las Vegas has a considerably shorter active-player injury list.

4. Panthers vs. Saints — Multiple IR Return Candidates

Carolina Panthers

  • RB: Jonathon Brooks (groin, FP, IR — designated to return), Trevor Etienne (ankle, FP)

  • WR: Xavier Legette (knee, FP, IR — designated to return)

  • OL: Brady Christensen (hamstring, FP, IR — designated to return), Damien Lewis (knee, FP), Torricelli Simpkins III (ankle, FP) RT Taylor Moton (ankle/OFS) LT Ikem Ekwonu (knee, IR)

  • LB: Bobby Okereke (foot, DNP)

  • EDGE: Jaelan Phillips (hamstring, FP)

  • CB: Mike Jackson (groin, FP, IR — designated to return), Will Lee III (hamstring, FP) Jayce Horn (IR)

New Orleans Saints

  • RB: CJ Donaldson (shoulder, DNP), Travis Etienne Jr. (hamstring, LP, IR — designated to return), Alvin Kamara (back/rest, DNP)

  • LT: Kelvin Banks Jr. (ankle, LP)

  • OL: David Edwards (knee, LP), Erik McCoy (biceps, DNP), Asim Richards (thumb, FP)

  • TE: Noah Fant (back, LP)

  • DL: Christen Miller (knee, LP)

  • CB: Martin Emerson Jr. (shin, LP)

Injury clusters: Carolina RB, OL and defensive front; New Orleans RB and OL.

Impact: Carolina could regain several contributors from IR, including Brooks, Legette, Christensen and Jackson. New Orleans has important offensive-line concerns involving McCoy and Banks, while Etienne is working toward returning from IR.

5. Vikings vs. Packers — Minnesota Quarterback and Green Bay Backfield

Minnesota Vikings

  • QB: Kyler Murray (hamstring, DNP, projected participation), Carson Wentz (ankle) traded for Kirk Cousins

  • TE: T.J. Hockenson (wrist/chest, DNP), Josh Oliver (IR)

  • OL: Donovan Jackson (IR)

  • LB: Jamal Adams (IR), Tyler Batty (IR)

Green Bay Packers

  • RB: Josh Jacobs (fractured finger, expected multiweek absence), Chris Brooks (ankle, IR — designated to return), MarShawn Lloyd (knee, no Wednesday injury designation)

  • WR: Jayden Reed (neck, long-term absence), Skyy Moore (IR)

  • TE: Luke Musgrave (IR)

  • DL: Javon Hargrave (IR), Warren Brinson (IR), Jonathan Ford (IR)

  • EDGE: Micah Parsons (knee, previous-week absence)

  • LB: Edgerrin Cooper (IR), Zaire Franklin (shin)

Injury clusters: Minnesota QB and TE; Green Bay RB, WR and defensive front.

Impact: Jacobs' fractured finger creates a significant change in Green Bay's backfield, with Kaleb Johnson potentially assuming lead duties. Minnesota has quarterback uncertainty with Murray's hamstring injury, while Hockenson missed Wednesday's practice.

6. Chiefs vs. Falcons — Kansas City Quarterback vs. Atlanta Offensive Injuries

Kansas City Chiefs

  • QB: Patrick Mahomes (right elbow, FP), Justin Fields (neck, FP)

  • WR: Tyquan Thornton (ankle, long-term absence), Jimmy Holiday (IR)

  • OT: Josh Simmons (IR)

  • DT: Omarr Norman-Lott (knee), Peter Woods (neck)

  • CB: L'Jarius Sneed (IR)

Atlanta Falcons

  • RB: Brian Robinson Jr. (hamstring, IR), Trey Sermon (IR)

  • WR: Zachariah Branch (hamstring, sidelined)

  • EDGE: Jalon Walker (IR), James Pierce (back,DNP)

  • DL: Da'Shawn Hand (IR)

  • LB: Divine Deablo (forearm, ongoing injury concern)

Injury clusters: Atlanta RB, WR and defensive front; Kansas City WR and defensive depth.

Impact: Mahomes practiced fully despite the elbow injury suffered against the Jets. Atlanta is missing Robinson and continues to have receiver concerns with Branch sidelined. Kansas City's quarterback situation appears substantially better than initially feared.

Check back for more updates ahead of Sunday!