The Detroit Lions enter their Week 2 matchup against the Buffalo Bills dealing with significantly more injury concerns, particularly on defense and along the offensive line.

Detroit enters the matchup with a Team SIC Score of 80.7 compared to Buffalo's 90.2, while several key Lions remain on injured reserve or PUP. Here's the latest injury report, player availability and team health outlook for Lions vs. Bills.

Buffalo Bills Injury Report

Terrel Bernard (LB, calf) — LP/LP/LP
Cole Bishop (S, knee/groin) — FP/LP/LP — Questionable
Bradley Chubb (OLB, thumb) — FP/FP/FP
Jordan Hancock (DB, quad) — FP/FP/FP
Ty Johnson (RB, hamstring) — LP/LP/LP — Questionable
T.J. Sanders (DL, knee/illness) — LP/DNP/LP — Questionable

Bills IR/PUP/NFI

Zane Durant (DT) — IR-R
Tyrell Shavers (WR, knee) — PUP-R
Demetrius Flannigan-Fowles (LB) — IR
Dorian Strong (CB, neck) — NFI-R

Detroit Lions Injury Report

Christian Mahogany (G, hip) — Out
Blake Miller (T, knee) — Out
D.J. Reed (CB, foot) — Questionable

Lions IR/PUP

Isiah Pacheco (RB, back/MCL) — IR/PUP
Cade Mays (C, wrist) — IR/PUP
Brian Branch (S, Achilles) — IR/PUP
Kerby Joseph (S, knee) — IR/PUP

The Lions are also without Branch and Joseph in the secondary, contributing to Detroit's Defense SIC Score of just 77.0.

Lions vs. Bills Team SIC Scores

Buffalo enters Week 2 with the healthier overall roster according to the SIC Scores.

Buffalo Bills
Team SIC Score: 90.2
Offense SIC Score: 93.2
Defense SIC Score: 87.2

Detroit Lions
Team SIC Score: 80.7
Offense SIC Score: 84.3
Defense SIC Score: 77.0

Buffalo holds a 9.5-point advantage in overall Team SIC Score, with the largest health disparity coming on defense. Detroit's 77.0 Defense SIC Score trails Buffalo's 87.2 entering the matchup.